By R.Davies, PhD・Exercise
Published on November 07, 2025
Building muscle (also known as muscle "hypertrophy") works by increasing the size of your individual muscle cells, usually via specific training and nutritional strategies. This article explains the fundamental evidence-based muscle-building principles for beginners.
The truth is, effective muscle growth follows well-established scientific principles that have been validated through decades of research and centuries of practice.
You don’t need complicated programmes, expensive supplements, "secret" techniques, hacks, or fancy equipment to build muscle. In this article, we've created a short evidence-based checklist that distils muscle growth down to the fundamentals.
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How close you get to your maximum capacity (sometimes referred to as "muscular failure") is one of the strongest predictors of muscle growth [1]. Finishing the set within a few repetitions of failure is best for growth.
Why Train Hard? When you train to (or near) failure, you start to use more of your muscle cells (or muscle "fibres"). This creates the mechanical tension that is needed to stimulate the maximum amount of growth in the largest number of muscle fibres possible.
This doesn’t mean every set needs to be taken to complete failure, but each of your “working sets” should challenge you.
Aim to finish each set feeling like you could only complete 1–3 more repetitions with good form. Use measures like the RPE ("Rating of Perceived Exertion") or RIR ("repetitions in reserve") to gauge your effort level.
The key here is to progressively "overload" your muscles, which just means gradually increasing the amount of work they are doing over time. This can be done by adding more weight, doing more repetitions, or doing more difficult exercises, while maintaining the same amount of (high) effort.
Volume per session also matters for muscle growth [2]. Performing multiple sets per exercise is generally better than a single set. To achieve weekly volume targets, you’ll probably have to do at least 3 sets per muscle group per session.
Multiple sets allow you to accumulate greater mechanical tension and metabolic stress in the muscle — two key drivers of hypertrophy. If you have time, you can do up to 12 sets per muscle group, as long as you can still hit your target loads throughout the session.
The mid-range of about 6 sets per muscle group per session using 2–3 different exercises is most common.
Structure your workouts to include 3–12 working sets for each major muscle group you’re targeting that day. This could be across 1–6 different exercises.
This might seem lower than most recommendations, but consider that warm-up/ramp-up sets don’t count toward this total. Only sets performed at high intensity (near failure) qualify as “working sets”.
Rest periods between sets should be enough to maintain performance without wasting precious time. Usually, this is 1–3 minutes, depending on personal preferences and your recovery time.
Weekly training volume is the total number of working sets performed per muscle group across all sessions. It is one of the strongest predictors of muscle growth; 12 to 20 sets per muscle group per week will optimise muscle growth for most people [3].
This range allows an adequate growth stimulus while avoiding "excessive" fatigue, which just prolongs recovery and wastes time (without adding any extra muscle growth).
Beginners may start to see good results with even lower volumes. While older adults may benefit from higher weekly volumes.
Track your weekly sets for each major muscle group. Remember that “compound” movements (e.g., deadlift, squat, bench press) count as multiple muscle groups being worked at the same time.
Training frequency (how often you train each muscle group) also seems to affect muscle growth. Research shows that training each muscle group 2 (or more) times a week is better than once a week [4].
If you train more often, you can also distribute your weekly volume across multiple sessions. This allows for more recovery, which generally means better training performance and technique, and thus more efficient muscle growth.
Design your training split to hit each muscle group at least twice per week. This could be:
This advice may contrast with the traditional 1 muscle group per week split. However, remember that the number of sets per muscle group per session is lower (as few as three).
Also, remember that multiple muscle groups can (and should) be worked in a single session, and compound exercises count as working more than 1 muscle group at a time.
There are over 600 muscles in the human body, and scientists have grouped them in dozens of different ways. There is no grand consensus. So, for movement and muscle growth, it might be useful to think about splitting your body into 4 major muscle groups.
Divide your body into the upper body and the lower body (split at the waist). Then divide your upper and lower body into pulling and pushing muscle groups again.
If you're doing big compound free-weight movements, you're rarely working any muscle group in complete isolation.
Some "push" exercises (e.g., bench press) also work "pull" muscles (e.g., lat muscle), although to a lesser degree. Some muscles (e.g., glutes and abs) are fully working in both "push" and "pull" exercises (e.g., squat and deadlift).
So, splitting the body up this way is not an exact science; it is just a way to ensure that you're working all major muscle groups, every week, somewhat equally.
Recovery between training sessions is crucial for growth. The muscle growth processes remains elevated for 24+ hours after training. So, an adequate amount of rest is needed for repair and growth to occur optimally.
Training a muscle repeatedly whilst it is fatigued and sore can impair growth, increase injury risk and lead to overtraining.
Delayed onset muscle soreness (DOMS) is an indicator of incomplete recovery, although simply "not having any DOMS" doesn't mean you are fully recovered either. Persistent soreness, poor performance, or feelings of fatigue may indicate that you're not getting enough rest.
If you're training at a high level of effort allow 1 full day (or at least 48 hours) between training sessions. There is little point in training for growth when fatigued or sore.
So if you trained your chest on Monday morning, avoid heavy pressing movements until Wednesday afternoon. If you are still sore and unable to hit the target weights on Wednesday, stop, do something else, and give yourself more time to rest.
A bit of light movement and active recovery are fine and can actually be beneficial, but avoid any high-intensity training of the exercised muscles.
Track your performance and soreness levels. If you’re consistently weaker or experiencing persistent soreness, consider adding an extra rest day or reducing training volume temporarily.
Quality always trumps quantity as far as muscle building is concerned.
Sleep is when the majority of muscle growth occurs. During deep sleep, anabolic hormone levels peak, muscle growth processes accelerate, and the repair processes run at full pace.
Research shows that poor sleep impairs muscle growth and your recovery (which goes on to impair your growth prospects further).
Quality matters as much as quantity. Sleep should be continuous, deep, and restorative. Poor sleep quality can blunt the anabolic response to training, even if the total amount of sleep appears adequate.
Read our full (free) evidence-based articles on optimising your sleep, which cover what to eat and what to do for better sleep, how long, what position, and what to look out for.
Protein intake is fundamental for muscle growth; you can't build muscle without it. Protein provides the amino acid building blocks your muscle needs to grow.
Protein intakes of 1.4–2.0 grams per kilogram of body mass daily are probably optimal for muscle growth when training [5].
Distribution matters as well. Spreading protein across 3–6 meals throughout the day increases your chances of getting enough protein throughout the day.
For a 75 kg person, aim for 104–150 grams of protein a day. Distribute it across 3–6 meals and snacks, targeting 20–50 grams every time you eat. Include protein sources at breakfast, lunch, dinner, and snacks (e.g., pre-bed, pre-workout, post-workout or between main meals).
Protein quality (i.e., the amino acid profile and its digestibility) probably affects muscle growth as well. Research shows that animal proteins are generally “complete,” meaning they contain all essential amino acids in optimal ratios for muscle growth.
Plant proteins often require combining different sources to achieve complete amino acid profiles. "Leucine" content of the protein is particularly important, as it acts as a key trigger for muscle growth.
Animal proteins typically provide higher leucine content per serving compared to most plant proteins.
If consuming animal proteins, include sources like chicken, fish, eggs, dairy, and lean red meats. These provide complete amino acid profiles with high leucine content and excellent digestibility.
For plant-based diets, combine complementary proteins like rice and beans, or consume varied protein sources throughout the day.
Consider plant protein powders (soy, pea, hemp, or blended plant proteins) to help meet daily targets and improve amino acid profiles if you can’t consume enough animal proteins.
You can use animal protein powders (e.g., whey, casein, or blend) if you can’t meet daily protein targets through your diet.
Eating enough calories supports muscle growth by ensuring that "growth-critical" processes (like muscle protein synthesis and training performance) are fuelled.
While you can build muscle in caloric deficits, adequate energy intake optimises the growth process and supports training intensity (which is needed for optimal muscle growth).
Individual calorie needs vary based on your body size, sex, age, activity level, and many other things.
Men typically need more calories than women due to greater muscle mass and higher metabolic rates. Active people also need more energy than sedentary people. Younger adults generally need more calories than older adults.
The amount of energy you need ranges from 30–50 kcal per kg body mass per day, but can be outside this range as well.
A 75 kg active male wanting to maintain body weight might target 40 kcal per kg body mass per day (~3,000 kcal). It’s best to start with conservative estimates and adjust based on body weight changes, your performance and how you generally feel.
Research shows a slight calorie surplus (300–500 kcal above maintenance) promotes muscle growth while minimising the amount of fat you gain. Very large energy surpluses may speed up muscle growth but also promote fat storage. Track your intake and body weight to fine-tune calorie needs.
Proper hydration supports muscle function, the muscle-building process, and exercise performance.
Dehydration can impair strength, power, and training capacity, which ultimately limits muscle growth [6]. Water also facilitates the transport of nutrients into the muscle and removes waste products from it.
Hard training increases fluid losses because you sweat and breathe more. This means that if you need to increase intake beyond basic needs.
Hot environments and long and intense training sessions increase fluid intake requirements further. A rough estimate of 30–40 ml per kg body mass per day (2+ litres per day), plus any training losses if fine.
A 75 kg individual should consume 2.25–3.0 litres per day, plus extra water during and after training. Our 75kg man should consume 375–525 ml (or 5-7 ml per kg body mass) within the 4 hours before training to ensure optimal performance.
Sip fluid during and after training. Plain water is usually fine, but sports drinks containing salts and sugars can be used if you're exercising and sweating heavily during training.
Thirst is a late indicator, so drink regularly throughout the day rather than waiting til you are thirsty to drink.
Consuming other "macronutrients" besides protein (i.e., carbohydrate and fats) will spare your dietary protein and muscle from being broken down and used for energy. Carbohydrates also fuel high-intensity training sessions and support recovery by replenishing your muscle fuel stores.
Adequate carbohydrate intake helps maintain training performance and may indirectly support muscle growth by enabling higher training volumes.
Dietary fat is also essential for hormone production (including testosterone and growth hormone), which influences your muscle-building capacity. Very low-fat diets can impair the production of testosterone and limit muscle growth.
There are no strict guidelines on how to divide the rest of your energy intake between carbohydrates and fats. General advice is 15–30 % total calories from “healthy” fats (not trans, not too much saturated fat either) and 3–5 g carbohydrate per kg body mass per day (or possibly up to 7 g per kg if you're training heavily).
A 75 kg person might consume 150–375 g of carbohydrates a day. Time carbohydrate intake around workouts and before bed for optimal fuel replenishment and to support performance.
Include healthy fats from sources like olive oil, nuts, avocados, and fatty fish. Balance these macronutrients with your protein target to create a muscle-building nutrition plan.
"Micronutrients" (vitamins and minerals) support thousands of processes that are involved in muscle growth, including muscle protein synthesis, making energy available, and repairing damaged tissues. Micronutrient deficiencies can impair training performance, recovery, and growth.
A varied, balanced diet typically provides adequate micronutrients for building muscle. Whole foods offer nutrients in “bioavailable” form, which some supplements may lack.
Vitamin or mineral supplements can be used to target specific deficiencies rather than serve as insurance against poor dietary choices.
Consume a variety of minimally processed fruits and vegetables, grains, pulses, lean proteins, and healthy fats. It’s not that complicated. The Mediterranean-style diet is probably the healthiest around; it is a good place to start if you're looking for guidance.
Consider basic supplementation only for nutrients difficult to get through food (vitamin D in low-sun climates, vitamin B12 for vegans) or if blood work or you have symptoms that reveal deficiencies.
Avoid expensive multivitamins or exotic supplements that promise "muscle-building benefits" — there is little evidence that “megadosing” of any micronutrients promotes muscle growth.
|
What |
How Much |
|---|---|
|
Sessions |
2+ a week |
|
Effort Level |
High or Near Maximal |
|
Sets per week |
12-20 per muscle group |
|
Load |
30-90% one-rep max |
|
Protein a day |
1.4–2.0 g per kg body mass |
|
Calories a day |
30–50 per kg body mass |
|
Fluid a day |
30–40 ml per kg body mass |
|
Sleep |
7–9 hours of quality sleep |
|
Rest |
48+ hours between sessions |
Building muscle doesn’t need complicated strategies, expensive supplements, or novel and revolutionary techniques.
It requires consistent application of a few fundamental principles backed by decades of scientific research. It is best to master these basics before seeking advanced methods or shortcuts.
This article is designed to cover the basics for each key aspect of muscle growth: training, nutrition and recovery. It is a starting point or checkpoint, not the final destination.
There is no natural miracle potion for muscle growth. Effective and efficient growth using these methods comes from consistency over time.
The information in this article isn’t an exact prescription; individual refinements and gradual improvements can be made in each area with trial-and-error and a bit of common sense.
1. Schoenfeld BJ et al. Loading Recommendations for Muscle Strength, Hypertrophy, and Local Endurance: A Re-Examination of the Repetition Continuum. Sports (Basel). 2021 Feb 22;9(2):32. PMID: 33671664
2. Schoenfeld BJ et al. Resistance Training Volume Enhances Muscle Hypertrophy but Not Strength in Trained Men. Med Sci Sports Exerc. 2019 Jan;51(1):94-103. PMID: 30153194
3. Baz-Valle E et al. A Systematic Review of The Effects of Different Resistance Training Volumes on Muscle Hypertrophy. J Hum Kinet. 2022 Feb 10;81:199-210. doi: 10.2478/hukin-2022-0017. PMID: 35291645; PMCID: PMC8884877. PMID: 35291645
4. Schoenfeld BJ et al. How many times per week should a muscle be trained to maximize muscle hypertrophy? A systematic review and meta-analysis of studies examining the effects of resistance training frequency. J Sports Sci. 2019 Jun;37(11):1286-1295. PMID: 30558493.
5. Jäger R et al. International Society of Sports Nutrition Position Stand: protein and exercise. J Int Soc Sports Nutr. 2017 Jun 20;14:20. PMID: 17909410
6. Judelson DA et al. Effect of hydration state on strength, power, and resistance exercise performance. Med Sci Sports Exerc. 2007 Oct;39(10):1817-24. PMID: 17909410
Published: November 07, 2025
Last Updated: April 02, 2026
Lead Author: R.Davies, PhD | Author Bio
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