What Is VO2max?
VO2max is shorthand for maximal oxygen uptake: the highest rate at which your body can use oxygen. It is measured in litres of oxygen per minute (L/min), or (more commonly) millilitres per kilogram of body weight per minute (mL/kg/min) to account for different body sizes.
All things being equal, a larger person will have a larger VO2max (L/min) because they have larger lungs, a larger heart, and more cells, which use more oxygen. This is why scientists correct for body size by dividing it by body mass ('per kg').
The best way to think of VO2max is the engine size (of your cardiovascular system): the bigger your VO2max, the more oxygen your muscles can use to create energy, and so the faster or longer you can keep exercising [1]. Your VO2max is determined partly by genetics (about half of it). But it also responds strongly to training [2]. Things like how well your heart and blood vessels circulate oxygen-rich blood and how efficiently your muscles use the oxygen can be improved with the right type of regular exercise.
How VO2max Changes: The Physiology
“Oxygen Output”
For most people, the strength and stamina of the heart is the limiting factor that determines VO2max. Exercise training can increase the amount of oxygen-rich blood your heart can pump to your muscles. Just like other muscles in your body, your heart can get bigger and stronger when regularly asked to work hard.
A well-trained athlete can pump nearly twice as much blood (per beat) as an unfit person. This is why an athlete's resting heart rate is usually a lot lower, because it pumps more blood per beat even when resting.
“Oxygen Delivery”
Regular exercise training stimulates the growth of new blood vessels around your muscles, meaning it can be delivered more easily. Exercise also increases the amount of blood you have, so it can carry more oxygen. So, more blood plus more blood vessels means more oxygen ends up getting delivered to your muscles.
“Oxygen Extraction”
Regular exercise can also increase how much oxygen your muscles can extract (and use) from your blood. The way it does this is by increasing the number and density of small 'organelles' in the muscle called mitochondria. The more mitochondria you have, the more oxygen you can use, the more energy you make, and the longer and harder you can exercise.
Why does VO2max decline?
Half of the battle throughout life is preventing your VO2max from decreasing, and there are three main ways that it does this.
Detraining
As little as two weeks of inactivity can reduce how well your heart pumps blood, the amount of blood you have and how well your muscles extract oxygen. Saying physically active is probably the most important thing you can do to maintain your VO2max.
Ageing
Unfortunately, your VO2max starts to drop as you age. You can slow the decline, but you can’t stop it entirely. That's life. Your heart, blood vessels and muscles get worn out over time and work less efficiently.
Injury or Illness
Most long-term illnesses or serious acute ones (particularly ones that affect your heart, lungs or require bed rest) will cause quite quick and dramatic decreases in your VO2max. The good news is that when you recover from them, you can regain losses.
Why VO2max Matters for Your Health
Beyond exercise performance, VO2max is one of the strongest predictors of overall health, heart health, metabolic health, brain health, healthy ageing, physical function, quality of life and life expectancy [3]. In fact, some researchers argue that VO2max is the most useful measure of health, more important than many standard blood tests or resting measures for predicting long-term overall health.
What Is a Good VO2max for Your Age?
Although VO2max naturally declines with age, those who regularly exercise will have better scores than their younger sedentary peers. The table below gives some general benchmarks for adults (in mL per kg per minute) [4].